TABLE 2.
Ex vivo drug susceptibilities of field isolates from Benin and reference clones
| Drug | No. of isolates tested | Geometric mean IC50 (nM) | 95% confidence interval (nM) | 3D7 geometric mean IC50 (nM) | W2 geometric mean IC50 (nM) | % of isolates (no./total) with a higher IC50 than 3D7 |
|---|---|---|---|---|---|---|
| DEAQ | 101 | 19.6 | 6.1–62.5 | 20.6 | 79.5 | 34.6 (35/101) |
| LUM | 90 | 9.3 | 1.9–49.6 | 23.2 | 29.9 | 8.9 (8/90) |
| DHA | 95 | 3.1 | 0.7–12.8 | 1.9 | 1.2 | 76.8 (73/95) |
| MQ | 79 | 9.8 | 2.1–45.4 | 49.9 | 45.7 | 3.8 (3/79) |
| QN | 83 | 71.2 | 23.0–220.6 | 129.9 | 528.7 | 15.7 (13/83) |
| PYR | 58 | 3,577 | 194–66,057 | 876.9 | NDa | 89.7 (52/58) |
a
ND, not done.