FIG 6.

Genetic relationships among pfdhfr alleles in southern China. Based on 7-loci microsatellite polymorphism around pfdhfr, all these isolates (n = 249) were classified into 174 haplotypes. The sizes of the circles are proportional to the number of isolates showing particular 7-loci microsatellite haplotypes. Six types of pfdhfr alleles are showed in different colors. White dots connecting haplotypes within the network are hypothetical median vectors generated by the software. Two major independent networks, designated YN/SEA types and HN type I, are formed simultaneously in the population (circles with solid line). The HN type II circle (dashed line) represents partial Hainan isolates with double mutants belong to the YN/SEA type.