TABLE 3.

Itraconazole and itraconazole/hydroxyitraconazole concentrations in serum and plasma samples

Assay and drug	No. of levels measured	Concn range (μg/ml)	Median quantifiable concn (μg/ml)	% of measurements below LLQa	% of measurements below 0.5 μg/ml	% of measurements above 17.1 μg/ml	Median matched hydroxyitraconazole/itraconazole ratio (range)
UPLC/MS
Itraconazole	689	Undetectable–7.37	0.84	38	54.60		1.59 (0.2–3.63)
Hydroxyitraconazole	676	Undetectable–7.31	1.13	25.30
Itraconazole + hydroxyitraconazole	651	Undetectable–14.01	1.71	26.30	42.40
Bioassay
Itraconazole/hydroxyitraconazole	3,105	Undetectable–>20	4.75	18		3.00

^aThe lower limit of quantification (LLQ) was <0.25 μg/ml for UPLC/MS and <0.5 μg/ml for bioassay.