TABLE 2.
Isolate | Yr | Source | MIC (μg/ml) |
FKS alterationb |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
FKS1 HS1 | FKS2 HS1 | FKS2 HS2 | Non-HS |
||||||||
Micafungin | Anidulafungin | Caspofungin | Fluconazole | FKS1 | FKS2 | ||||||
46228A | 2011 | South Africa | 0.015 | 0.06 | 0.25 | 128 | Neg | Neg | Neg | Y1279F | T926P |
49889F | 2011 | Canada | 0.015 | 0.03 | 0.25 | 32 | Neg | Neg | Neg | Neg | G680S |
10729J | 2004 | United Kingdom | 0.015 | 0.06 | 0.25 | 1 | Neg | Neg | Neg | L195F | Neg |
10685J | 2004 | Spain | 0.015 | 0.06 | 0.25 | 32 | Neg | Neg | Neg | Neg | F384Y |
10702J | 2005 | Spain | 0.015 | 0.12 | 0.25 | 16 | Neg | Neg | Neg | A995T | Neg |
10728J | 2002 | Spain | 0.015 | 0.06 | 0.25 | 1 | Neg | Neg | Neg | D140Y, A1749V | Neg |
44075F | 2011 | Washington | 0.03 | 0.06 | 0.12 | 32 | Neg | Neg | Neg | Neg | T926P |
17823F | 2011 | Michigan | 0.06 | 0.12 | 0.06 | 128 | Neg | Neg | Neg | Neg | A450T |
10708J | 2005 | Poland | 0.06 | 0.25 | 0.25 | 16 | Neg | Neg | Neg | A1749V | Neg |
760F | 2008 | Washington | 0.12 | 0.5 | 0.25 | 4 | Neg | S663F | Neg | Neg | T926P |
37706F | 2011 | United States | 0.5 | 1 | 0.5 | 8 | Neg | S663Y | Neg | Neg | G680S |
10700J | 2004 | Japan | 0.5 | 2 | 1 | 64 | Neg | L662W | Neg | Neg | E78D, T926P |
49079F | 2011 | Australia | 2 | 2 | 2 | >128 | Neg | S663P | Neg | Neg | T926P |
Strains were collected from 2001 to 2011 in two global surveillance studies.
Neg, Negative.