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(A) Determination of the hLF concentration against circulating A. actinomycetemcomitans in LFKO−/− mice. Mice (n = 4) were injected with hLF (100 to 500 μg/g of body weight) 2 h before injection of A. actinomycetemcomitans (1 × 107). Bacterial counts in the blood after 6 h are expressed as mean CFU/ml of blood. Asterisks indicate significance (P < 0.05) of differences in the bacterial counts between hLF-treated and untreated groups, as calculated from duplicates by Student's t test.
