TABLE 2.
Parameter estimates of the final moxifloxacin pharmacokinetic modela
| Parameter | Value(s) (RSE[%]) |
|
|---|---|---|
| Typical | IIVb | |
| CL (liters/h) | 10.6 (2.68) | 18.7 (4.05) |
| Vc (liters) | 114 (1.36) | |
| ka (h−1) | 1.50 (2.15) | 69.9 (3.62) |
| MTT (h) | 0.723 (7.02) | 73.4 (2.58) |
| No. of transit compartments | 11.6 (2.39) | |
| Q (liters/h) | 2.14 (2.92) | 32.9 (3.17) |
| Vp (liters) | 89.8 (3.66) | |
| F | 1 FIX | 17.7 (3.28) |
| Proportional error (%) | 7.85 (1.44) | |
RSE, relative standard error reported on the approximate standard-deviation scale obtained from a bootstrap sample size of 200; CL, oral clearance; Vc, volume of distribution in the central compartment; ka, first-order absorption rate constant; MTT, absorption mean transit time; Q, intercompartmental clearance; Vp, volume of distribution in the peripheral compartment; F, oral bioavailability fixed to 1 (since we did not have intravenous injection data). In this table, we report the values of parameters directly estimated by the model. To obtain CL/F, the values of CL must be combined with those of F. Since the typical value of F was fixed to 1, the typical value of CL/F has the same value as CL, while the between-subject variability (BSV) of CL/F needs to take into account both the BSV in CL and that in F. A similar consideration is valid for Vc/F, Q/F, and Vp/F.
IIV, interindividual variability expressed as percent coefficient of variation (% CV).