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Killing kinetics of AZD5847 (A) and linezolid (B) in murine bone marrow-derived macrophages infected with M. tuberculosis. (C) The concentration-response curve against M. tuberculosis in bone marrow-derived macrophages on day 10 for AZD5847 and linezolid is shown. Lines were obtained by fitting these data to the Emax model (equation 2, as described in Materials and Methods).
