TABLE 1.
Distribution of MICs across various reference and clinical isolates of M. tuberculosis, including single-drug-resistant strainsa
| M. tuberculosis strain | Origin | MIC (μg/ml) |
|||||
|---|---|---|---|---|---|---|---|
| STR | INH | RIF | EMB | OFL | AZD5847 | ||
| ATCC 27294 | Reference strain | 0.25–0.5 | 0.03 | 0.015 | 2–4 | 0.5–1 | 1 |
| ATCC 35811 | Reference strain | 0.25–0.5 | 0.03 | 0.06 | 8 | 0.5–1 | 0.5 |
| ATCC 25618 | Reference strain | 0.25–0.5 | 0.06 | 0.03 | 4 | 1 | 0.5 |
| Erdman | Reference strain | 0.125–0.25 | 0.06 | 0.03 | 4 | 0.25 | 0.5 |
| Beijing | Reference strain | 0.125–0.25 | 0.06 | 0.03 | 8 | 0.5 | 0.25 |
| Harlingen | Reference strain | ≤0.5 | 0.03 | 0.03 | 8 | 0.5 | 0.25 |
| CDC1551 | Reference strain | 0.25 | 0.03 | 0.03 | 8 | 0.5 | 0.5 |
| ATCC 35820 STRr | Reference strain | >8 | 0.03 | 0.03 | 4 | 0.5 | 1 |
| ATCC 35822 INHr | Reference strain | 0.25–0.5 | >128 | 0.015 | 4 | 0.5–1 | 1 |
| DKU220 | Sputum isolate | 0.125 | 0.125 | 0.015 | 4 | 0.5 | 0.5 |
| DK97A | Sputum isolate | 0.125 | 0.06 | 0.03 | 4 | 0.5 | 0.13 |
| DP299S | Sputum isolate | 0.25 | 0.03 | 0.06 | 4 | 0.5 | 1 |
| 136570 STRr | Sputum isolate | >4 | 0.03 | 0.03 | 2 | 0.5 | 1 |
| 912253 INHr | Sputum isolate | 0.25 | >1 | 0.03 | 4 | 0.5 | 0.5 |
| JALMA RIFr | Sputum isolate | 0.25 | 0.06 | >0.5 | 4 | 0.5 | 0.5 |
| 19000 RIFr | Sputum isolate | 0.06–0.125 | 0.06 | >8 | 4 | 0.25–0.5 | 0.5 |
| 17003 EMBr | Sputum isolate | ≤0.5 | 0.03 | 0.03 | >32 | 0.5 | 0.13 |
| 12119 OFLr | Sputum isolate | 0.125–0.5 | 0.06 | 0.008 | 2 | >4 | 1 |
a
The MIC was determined following drug exposure, and growth was monitored by turbidometry. STR, streptomycin; INH, isoniazid; RIF, rifampin; EMB, ethambutol; OFL, ofloxacin.