TABLE 3.
In pairwise combination studies, AZD5847 exerts additivity with known TB drugs
| Drug combination | MIC (μg/ml) |
ΣFICa | |
|---|---|---|---|
| Alone | Combinationb | ||
| AZD5847 | 0.5 | 0.5 | 1.13 |
| Isoniazid | 0.03 | 0.004 | |
| AZD5847 | 0.5 | 0.125 | 0.8 |
| Rifampin | 0.015 | 0.008 | |
| AZD5847 | 0.5 | 0.5 | 1.12 |
| Ethambutol | 1 | 0.125 | |
| AZD5847 | 0.5 | 0.5 | 1.24 |
| Streptomycin | 0.25 | 0.06 | |
| AZD5847 | 0.5 | 0.5 | 1.06 |
| Moxifloxacin | 0.125 | 0.008 | |
a
A ΣFIC (fractional inhibitory concentration [FIC] index) value of ≤0.5 denotes synergy, one of ≥4.0 denotes antagonism, and values in between denote additivity.
b
The MIC in the combination was determined using a checkerboard method.