TABLE 5.

Spontaneous resistance to AZD5847 and linezolid maps to the rrl and rplC genes in M. tuberculosis^a

Strain	MIC (μg/ml)					Mutation
	AZD5847	Linezolid	Moxifloxacin	Isoniazid	Rifampin	rrl gene	rplC gene	L3 protein
H37Rv (ATCC 27294)	1	1	0.13	0.06	0.02	WT	WT	WT
5847r-4.1	16	16	0.13	0.06	0.02	WT	T460C	Cys154Arg
5847r-4.6	16	16	0.13	0.06	0.02	WT	T460C	Cys154Arg
5847r-8.8	16	16	0.13	0.06	0.02	WT	T460C	Cys154Arg
5847r-8.9	16	16	0.13	0.06	0.02	WT	T460C	Cys154Arg
5847r-8.10	16	8	0.13	0.06	0.02	G2270T	WT	WT
LNZr-8.1	16	16	0.13	0.06	0.02	WT	T460C	Cys154Arg
LNZr-8.3	160	16	0.13	0.06	0.02	WT	T460C	Cys154Arg
LNZr-8.7	16	32	0.13	0.125	0.02	WT	T460C	Cys154Arg

^aWT, wild type; LNZ^r, linezolid-resistant M. tuberculosis; 5847^r, AZD5847-resistant M. tuberculosis.