TABLE 1.
Antibiotic susceptibility of P. aeruginosa ΔfabY mutant and wild-type strains
| Antibiotic | MIC (μg/ml)a |
Fold change | |
|---|---|---|---|
| Wild type | ΔfabY mutant | ||
| Vancomycin | >1,024 | 32 (>1,024) | >32 |
| Cefotaxime | 32 | 1 | 32 |
| Ceftriaxone | 16 | 0.5 | 32 |
| Ceftazidime | 1 | 0.06 (2) | 16 |
| Carbenicillin | 64 | 4 | 16 |
| Ticarcillin | 32 | 2 | 16 |
| Imipenem | 1 | 0.125 | 8 |
| Meropenem | 0.5 | 0.125 | 4 |
| Rifampin | 32 | 4 | 8 |
| Tetracycline | 32 | 8 | 4 |
| Minocycline | 16 | 4 | 4 |
| Erythromycin | 512 | 128 | 4 |
| Azithromycin | 256 | 64 | 4 |
| Chloramphenicol | 32 | 16 | 2 |
| Ofloxacin | 1 | 0.25 | 4 |
| Ciprofloxacin | 0.25 | 0.12 (0.12) | 2 |
| Amikacin | 4 | 2 | 2 |
| Tobramycin | 0.5 | 0.25 | 2 |
| Sulfamethoxazole | 256 | 128 | 2 |
| Trimethoprim | 128 | 256 (128) | 0.5 |
| Polymyxin B | 1 | 0.5 | 2 |
| Colistin | 1 | 1 | 1 |
| Chlorhexidine | 16 | 16 | 1 |
a
MIC measured in MHB broth. MICs in parentheses correspond to the plasmid-complemented ΔfabY (pfabY) strain TMT41.