TABLE 2.
Mutations in the QRDRs of gyrA and gyrB and FQ MICs
| Mutation in QRDR of gyrA | Mutation in QRDR of gyrB | No. (%) of isolates | MIC range (mg/liter) |
||||
|---|---|---|---|---|---|---|---|
| OFX | LFX | MXF | GAT | SPX | |||
| Gly88Ala | 2 (1.4) | 2.0 | 2.0 | 0.5–1.0 | 0.25 | 0.25 | |
| Asp89Asn | 3 (2.2) | 2.0–4.0 | 1.0–2.0 | 0.25–1.0 | 0.25 | 0.25–0.5 | |
| Ala90Val | 31 (22.5) | 2.0–8.0 | 1.0–8.0 | 0.25–8.0 | ≤0.125–1 | ≤0.125–2.0 | |
| Ser91Pro | 5 (3.6) | 2.0–4.0 | 2.0 | 0.5–2.0 | 0.25 | 0.25 | |
| Asp94His | 3 (2.2) | 4.0–32.0 | 4.0–8.0 | 4.0–8.0 | 0.25–2.0 | 1.0–2.0 | |
| Asp94Tyr | 5 (3.6) | 4.0–8.0 | 2.0–4.0 | 0.5–8.0 | 0.25–1.0 | 0.25–1.0 | |
| Asp94Asn | 9 (6.5) | 8.0–16.0 | 2.0–8.0 | 2.0–8.0 | 0.25–4.0 | 1.0–2.0 | |
| Asp94Ala | 11 (8.0) | 2.0–4.0 | 1.0–2.0 | 0.25–4.0 | 0.25–0.5 | 0.25–1.0 | |
| Asp94Gly | 16 (11.6) | 4.0–16.0 | 2.0–4.0 | 0.5–8.0 | 0.25–1.0 | 0.25–2.0 | |
| Asp94Cys | 1 (0.7) | 8.0 | 8.0 | 2.0 | 0.5 | 0.5 | |
| Arg485His | 2 (1.4) | 4.0–16.0 | 4.0–8.0 | 8.0 | 0.5–2.0 | 1.0–2.0 | |
| Asp500Asn | 1 (0.7) | 8.0 | 2.0 | 0.5 | 0.25 | 0.5 | |
| Asp500Ala | 1 (0.7) | 4.0 | 2.0 | 1.0 | 0.5 | 2.0 | |
| Ala90Val | Ser486Tyr | 1 (0.7) | 4.0 | 2.0 | 4.0 | 0.5 | 0.5 |
| Asp94Asn | Asp538Thr | 1 (0.7) | 32.0 | 32.0 | 16.0 | 16.0 | 32.0 |
| Asp94Ala | Asp538Thr | 1 (0.7) | 8.0 | 2.0 | 4.0 | 1.0 | 4.0 |
| Total | 93 (67.4) | 2.0–32.0 | 1.0–32.0 | 1.0–16.0 | ≤0.125–16.0 | ≤0.125–32.0 | |