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. 2014 Jan;58(1):38–47. doi: 10.1128/AAC.01363-13

FIG 1.

FIG 1

Activity of GSK2336805 on NS5A variants in genotype 1a. GSK2336805 was profiled against a panel of NS5A variants observed in genotype 1a resistance screens with GSK2336805 or published genotype 1a amino acid changes leading to resistance for other NS5A inhibitors. Substitutions were made in the 1a fit replicon as described in Materials and Methods (18). Replicons containing the amino acid changes were tested in transient-transfection assays. The average EC50s are plotted on a log10 scale, and the error bars represent the 95% confidence intervals. Each replicon was tested at least 3 times.