FIG 3.
Activity of GSK2336805 on chimeric replicons containing genotype 1a and 1b NS5A patient sequences. GSK2336805 was tested in transient-transfection assays for activity on chimeric replicons containing genotype 1a or 1b patient sequences. The wild-type replicon is the genotype 1b Con-1 ET replicon, the backbone for the chimeric replicons, represented by the open circles. EC50s for each chimeric replicon are represented by black circles. The solid lines represent the mean EC50 for the chimeric replicons, and the dashed lines are the 95% confidence intervals for GSK2336805 activity. Each replicon was tested at least 3 times.