TABLE 4.

Activity of GSK2336805 on resistant variants raised by other HCV DAAs^a

HCV gene	Variant	EC50 (pM)		Fold shift from WT value	n
		Mean	95% CI
	WT	6.8	5.8–7.8		59
NS3	A156T	3.9	2.4–6.3	0.6	4
NS3	D168A	6.2	5.1, 7.4b	0.9	2
NS3	D168V	6.7	6.0, 7.4b	1.0	2
NS3	R155K	10.5	ND	1.5	1
NS4B	H94R	4.2	2.2–7.8	0.6	6
NS4B	V105L	11.4	7.1–18.2	1.7	6
NS5A	D320E	5.5	4.0–7.7	0.8	6
NS5B	C316N	4.3	3.0–6.2	0.6	12
NS5B	C316Y	4.4	3.1–6.3	0.7	12
NS5B	C445F	4.8	3.3–7.0	0.7	12
NS5B	H95Q	15.9	9.3–27.4	2.3	5
NS5B	M414T	2.2	0.7–4.1c	0.3	3
NS5B	N411S	17.5	11.0–27.7	2.6	5
NS5B	P495L	8.3	5.1–13.5	1.2	6
NS5B	P496S	10.6	4.4–25.1	1.6	6
NS5B	S365T	6.2	2.0–19.0	0.9	6
NS5B	S368T	7.6	2.7–21.4	1.1	6
NS5B	Y448H	3.9	2.9–5.3	0.6	12
NS5B	Y452H	4.7	3.5–6.4	0.7	12

^aCI, confidence interval; ND, not determined.

^bEC₅₀s are listed for n = 2.

^cRange of EC₅₀s is given for n = 3.