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Hydrogen bonding interactions made between oxacillin and the enzyme. (A) K70D OXA-1/oxacillin. Note that the side chain of Ser115 is shown in dual conformations. (B) K84D OXA-24/40/oxacillin. For clarity, the side chain of Trp221 is not shown. Hydrogen bonds are displayed as dashed yellow lines and represent distances between 2.5 and 3.2 Å. Water molecules are drawn as red spheres.
