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IC50s were determined for parent compounds and derivatives against hERG channels expressed in CHO cells, as measured by the Ionworks patch clamp assay. Representative graphs of quinine (A), HEAQ (B), quinidine (C), HEAQD (D), and HEQD (E) are pictured. The positive control, dofetilide, has an IC50 of 0.053 μM. Compounds were tested in quadruplicate in an 8-point gradient with a maximum concentration of 100 μM with serial 1:3 dilutions.
