TABLE 1.
Average IC50s of quinine and quinidine derivatives against three strains of P. falciparum determined by using a 72-h SYBR green assaya
| Compound | Avg IC50 (nM) (SEM) |
||
|---|---|---|---|
| 3D7 | INDO | Dd2 | |
| Quinine | 56 (6) | 263 (25) | 92.0 (10) |
| HEQ | 258 (33) | 7,100 (276) | 2,800 (363) |
| HEAQ | 255 (29) | 3,470 (429) | 1,133 (133) |
| HEAQ-HCl salt | 240 (77) | — | 1,250 (189) |
| Quinidine | 24 (2) | 153 (279) | 42.5 (1) |
| HEQD | 111 (22) | 1,875 (427) | 313 (13)b |
| HEAQD | 168 (25) | 725 (170) | 333 (44) |
| HEAQD-HCl salt | 148 (55) | — | 233 (17) |
| Artemisinin | 8.3 (1) | 5.1 (1) | 5.5 (1) |
a
Three or more biological replicates were completed for all compounds unless otherwise noted, with each compound in triplicate per experiment, reported with corresponding standards error of the means. —, no data for these compounds.
b
Two independent experiments were completed for this compound.