TABLE 1.
Comparative in vitro activity of 162 Clostridium strains analyzed by cluster to SMT19969, fidaxomicin, metronidazole, and vancomycin
| RMA no.a | Species | Clostridial cluster | MIC (μg/ml) |
|||
|---|---|---|---|---|---|---|
| SMT19969b | Fidaxomicin | Metronidazole | Vancomycin | |||
| 18328 | Clostridium baratii | I | >512 | ≤0.03 | 1 | 2 |
| 6392 | C. baratii-like | I | 0.5 | ≤0.03 | 1 | 2 |
| 19025 | Clostridium butyricum | I | 0.25 | 0.06 | 0.5 | 0.5 |
| 19848 | C. butyricum | I | 0.25 | ≤0.03 | 0.5 | 0.5 |
| 21418 | C. butyricum | I | 0.25 | 0.06 | 1 | 0.5 |
| 22044 | C. butyricum | I | 0.25 | 0.06 | 1 | 0.5 |
| 22081 | C. butyricum | I | 0.5 | 0.125 | 1 | 0.5 |
| 14198 | Clostridium cadaveris | I | 1 | ≤0.03 | 0.125 | 2 |
| 16516 | C. cadaveris | I | 2 | ≤0.03 | 0.125 | 2 |
| 16863 | C. cadaveris | I | 1 | 0.06 | 0.125 | 4 |
| 18944 | C. cadaveris | I | 32 | ≤0.03 | 0.125 | 2 |
| 19962 | C. cadaveris | I | 256 | 0.06 | 0.125 | 2 |
| 20805 | C. cadaveris | I | 0.25 | ≤0.03 | 0.06 | 2 |
| 6433 | Clostridium colicanis | I | 0.5 | ≤0.03 | 2 | >32 |
| 6786 | C. colicanis | I | 64 | ≤0.03 | 2 | 2 |
| 15999 | Clostridium disporicum | I | 0.06 | ≤0.03 | 1 | 0.5 |
| 21544 | C. disporicum | I | 0.25 | ≤0.03 | 0.25 | 0.25 |
| 12757 | Clostridium fallax | I | 0.125 | ≤0.03 | 0.5 | 0.5 |
| 21095 | C. fallax | I | 0.06 | ≤0.03 | 1 | 1 |
| 12522 | Clostridium novyi A | I | 0.25 | ≤0.03 | 1 | 0.5 |
| 15199 | Clostridium paraputrificum | I | 1 | 0.06 | 2 | 1 |
| 16518 | C. paraputrificum | I | 64 | ≤0.03 | 2 | 2 |
| 18947 | C. paraputrificum | I | 64 | ≤0.03 | 1 | 1 |
| 21627 | C. paraputrificum | I | 64 | ≤0.03 | 0.5 | 2 |
| 21630 | C. paraputrificum | I | 64 | ≤0.03 | 2 | 1 |
| 22852 | C. paraputrificum | I | 0.5 | ≤0.03 | 2 | 1 |
| 16521B | C. paraputrificum | I | 64 | ≤0.03 | 1 | 1 |
| 16597A | C. paraputrificum | I | 64 | ≤0.03 | 2 | 1 |
| 21966 | Clostridium perfringens | I | 256 | ≤0.03 | 1 | 1 |
| 22113 | C. perfringens | I | >512 | ≤0.03 | 2 | 1 |
| 22244 | C. perfringens | I | >512 | ≤0.03 | 0.5 | 1 |
| 22245 | C. perfringens | I | >512 | ≤0.03 | 1 | 1 |
| 22509 | C. perfringens | I | >512 | 0.06 | 4 | 1 |
| 22671 | C. perfringens | I | >512 | 0.06 | 4 | 1 |
| 22722 | C. perfringens | I | >512 | ≤0.03 | 2 | 1 |
| 22810 | C. perfringens | I | 64 | ≤0.03 | 1 | 1 |
| 22842 | C. perfringens | I | 256 | ≤0.03 | 2 | 1 |
| 22885 | C. perfringens | I | 1 | ≤0.03 | 0.5 | 1 |
| 23087 | C. perfringens | I | 8 | ≤0.03 | 4 | 1 |
| 21091 | Clostridium sardiniense | I | >512 | ≤0.03 | 4 | 32 |
| 9638 | Clostridium sporogenes | I | 0.5 | 0.06 | 0.25 | 4 |
| 10379 | C. sporogenes | I | 64 | 0.06 | 0.25 | 2 |
| 10900 | C. sporogenes | I | 64 | 0.06 | 0.25 | 4 |
| 15061 | C. sporogenes | I | 64 | 0.06 | 0.25 | 2 |
| 16077 | C. sporogenes | I | 4 | ≤0.03 | ≤0.06 | 2 |
| 15329 | Clostridium subterminale group | I | 0.125 | ≤0.03 | 0.25 | 1 |
| 18693 | C. subterminale group | I | 2 | ≤0.03 | 0.5 | 1 |
| 19908 | C. subterminale group | I | 0.125 | ≤0.03 | 0.5 | 0.5 |
| 20775 | C. subterminale group | I | 0.5 | ≤0.03 | 0.25 | 1 |
| 8622B | C. subterminale group | I | ≤0.03 | ≤0.03 | 0.5 | 1 |
| 14609 | Clostridium tertium | I | 0.5 | ≤0.03 | 1 | 2 |
| 16273 | C. tertium | I | 1 | ≤0.03 | 1 | 2 |
| 18836 | C. tertium | I | 4 | ≤0.03 | 2 | 2 |
| 19847 | C. tertium | I | 4 | ≤0.03 | 1 | 2 |
| 22841 | C. tertium | I | 0.5 | 0.06 | 2 | 2 |
| 18623 | Clostridium bartlettii | XI | 1 | ≤0.03 | 1 | 2 |
| 5262 | Clostridium bifermentans | XI | 0.125 | ≤0.03 | 0.5 | 0.5 |
| 5324 | C. bifermentans | XI | 0.5 | ≤0.03 | 0.5 | 0.5 |
| 9640 | C. bifermentans | XI | 0.5 | ≤0.03 | 0.5 | 0.5 |
| 9897 | C. bifermentans | XI | 0.5 | ≤0.03 | 0.5 | 0.5 |
| 9948 | C. bifermentans | XI | 0.5 | ≤0.03 | 0.5 | 1 |
| 21658 | C. bifermentans | XI | 0.25 | ≤0.03 | 1 | 0.5 |
| 9388B | C. bifermentans | XI | 0.25 | ≤0.03 | 2 | 0.5 |
| 8910 | Clostridium glycolicum | XI | 32 | ≤0.03 | 0.125 | 0.5 |
| 14467 | C. glycolicum | XI | 0.5 | 0.5 | 0.25 | 0.5 |
| 15023 | C. glycolicum | XI | 0.5 | 0.5 | 0.125 | 0.5 |
| 16312 | C. glycolicum | XI | 0.5 | 0.25 | 0.25 | 2 |
| 7121 | C. glycolicum-like | XI | 32 | 1 | 0.25 | 0.5 |
| 22811 | Clostridium mayombei-like | XI | 0.5 | 0.5 | 1 | 0.25 |
| 16782 | Clostridium sordellii | XI | 1 | ≤0.03 | 2 | 1 |
| 18788 | C. sordellii | XI | 64 | ≤0.03 | 4 | 1 |
| 21861 | C. sordellii | XI | 16 | ≤0.03 | 4 | 0.5 |
| 21976 | C. sordellii | XI | 1 | ≤0.03 | 8 | 1 |
| 22672 | C. sordellii | XI | 8 | 0.125 | 4 | 1 |
| 4634 | C. sordellii-like | XI | 2 | ≤0.03 | 1 | 1 |
| 16057 | Clostridium aldenense | XIVa | 0.5 | 64 | ≤0.06 | 1 |
| 18348 | C. aldenense | XIVa | 0.5 | 64 | ≤0.06 | 1 |
| 18939 | C. aldenense | XIVa | 0.5 | 64 | ≤0.06 | 1 |
| 23550 | C. aldenense | XIVa | 0.125 | 64 | ≤0.06 | 2 |
| 20918A | Clostridium aminovalericum | XIVa | 0.25 | 2 | 0.25 | 8 |
| 10036 | Clostridium bolteae | XIVa | 0.25 | 128 | ≤0.06 | 1 |
| 18941 | C. bolteae | XIVa | 0.5 | 128 | 0.125 | 2 |
| 21972 | C. bolteae | XIVa | 0.125 | 64 | 0.125 | 1 |
| 22131 | C. bolteae | XIVa | 0.5 | 64 | ≤0.06 | 1 |
| 12934 | Clostridium celerecrescens | XIVa | 0.125 | 8 | 0.5 | 1 |
| 19024 | C. celerecrescens | XIVa | 0.25 | 32 | 0.5 | 1 |
| 19963 | C. celerecrescens | XIVa | 0.5 | 32 | 0.5 | 1 |
| 15980 | Clostridium citroniae | XIVa | 0.125 | 64 | 0.25 | 1 |
| 21971 | C. citroniae | XIVa | 0.125 | 128 | 0.125 | 1 |
| 23088 | C. citroniae | XIVa | 0.125 | 64 | 0.125 | 1 |
| 16102A | C. citroniae | XIVa | 0.06 | 64 | ≤0.06 | 1 |
| 16521A | C. citroniae | XIVa | 0.25 | 64 | ≤0.06 | 1 |
| 20713 | Clostridium clostridioforme | XIVa | 0.125 | 64 | 0.25 | 1 |
| 21282 | C. clostridioforme | XIVa | 0.25 | 128 | ≤0.06 | 1 |
| 21626 | C. clostridioforme | XIVa | 0.25 | >128 | ≤0.06 | 2 |
| 22060 | C. clostridioforme | XIVa | 0.125 | 128 | ≤0.06 | 2 |
| 22084 | C. clostridioforme | XIVa | 0.25 | 128 | ≤0.06 | 2 |
| 18723 | Clostridium hathewayi | XIVa | 0.125 | 32 | 0.25 | 0.5 |
| 20145 | C. hathewayi | XIVa | 0.125 | 16 | 0.125 | 0.5 |
| 20647 | C. hathewayi | XIVa | 0.5 | 16 | 0.5 | 0.5 |
| 21975 | C. hathewayi | XIVa | 0.125 | 2 | 0.125 | 0.5 |
| 2489 | Clostridium hylemonae | XIVa | 0.06 | ≤0.03 | 0.5 | 1 |
| 13503 | C. hylemonae | XIVa | 0.5 | 0.25 | 0.25 | 2 |
| 15944 | C. hylemonae | XIVa | 0.5 | 0.25 | 0.125 | 2 |
| 16423 | C. hylemonae | XIVa | 0.5 | 0.25 | 0.125 | 2 |
| 16895 | C. hylemonae | XIVa | 0.5 | 0.25 | 0.125 | 2 |
| 18591 | C. hylemonae | XIVa | 0.5 | 0.25 | 0.25 | 2 |
| 22200 | C. hylemonae | XIVa | 0.5 | 0.25 | 0.25 | 2 |
| 15073A | C. hylemonae | XIVa | 0.5 | 0.25 | 0.125 | 1 |
| 10628 | Clostridium lavalense | XIVa | 0.5 | 0.06 | 0.125 | 1 |
| 12736 | Clostridium scindens | XIVa | 0.125 | 0.02 | 0.125 | 0.5 |
| 21863 | C. scindens | XIVa | 0.06 | 0.06 | 0.125 | 0.5 |
| 21878 | C. scindens | XIVa | 64 | 1 | 0.5 | 0.5 |
| 22045 | C. scindens | XIVa | 0.125 | 0.06 | 0.25 | 0.5 |
| 22624 | C. scindens | XIVa | 0.25 | 1 | 0.25 | 0.5 |
| 20753 | Clostridium symbiosum | XIVa | 0.25 | 4 | 0.125 | 1 |
| 21214 | C. symbiosum | XIVa | 0.5 | 2 | 0.125 | 0.5 |
| 21868 | C. symbiosum | XIVa | 1 | 8 | 0.25 | 1 |
| 22082 | C. symbiosum | XIVa | 0.25 | 2 | 0.25 | 1 |
| 22366 | C. symbiosum | XIVa | 0.125 | 2 | 0.125 | 1 |
| 20132 | Clostridium xylanolyticum | XIVa | 0.125 | 16 | 1 | 0.5 |
| 15167 | Clostridium lactatifermentans | XIVb | 0.06 | 0.06 | 0.25 | >32 |
| 5491 | Clostridium innocuum | XVI | 0.25 | >128 | 2 | 8 |
| 5615 | C. innocuum | XVI | 0.25 | >128 | 1 | 16 |
| 20638 | C. innocuum | XVI | 1 | 256 | 0.5 | 16 |
| 20645 | C. innocuum | XVI | 0.25 | 256 | 0.5 | 16 |
| 20648 | C. innocuum | XVI | 0.25 | 128 | 0.5 | 16 |
| 20913 | C. innocuum | XVI | 0.25 | 256 | 1 | 16 |
| 21213 | C. innocuum | XVI | 0.06 | 256 | 1 | 16 |
| 21737 | C. innocuum | XVI | 1 | 256 | 1 | 16 |
| 21860 | C. innocuum | XVI | 0.25 | 256 | 1 | 16 |
| 21903 | C. innocuum | XVI | 0.25 | 256 | 16 | 16 |
| 22441 | C. innocuum | XVI | 0.25 | 512 | 0.5 | 16 |
| 23130 | C. innocuum | XVI | 0.125 | 128 | 2 | 16 |
| 10072 | Clostridium rectum-like | XIX | >512 | >128 | 0.5 | >32 |
| 14707 | C. rectum-like | XIX | >512 | >128 | 1 | >32 |
| 16549 | C. rectum-like | XIX | 32 | >128 | 0.125 | >32 |
| 20917 | Clostridium ramosum | XVIII | >512 | >512 | 0.5 | 4 |
| 21212 | C. ramosum | XVIII | >512 | >512 | 0.5 | 4 |
| 21215 | C. ramosum | XVIII | >512 | >512 | 0.5 | 4 |
| 21414 | C. ramosum | XVIII | >512 | >512 | 8 | 4 |
| 21738 | C. ramosum | XVIII | 128 | >512 | 0.5 | 4 |
| 21862 | C. ramosum | XVIII | >512 | >512 | 0.5 | 4 |
| 21902 | C. ramosum | XVIII | 512 | >512 | 0.5 | 4 |
| 21974 | C. ramosum | XVIII | 512 | >512 | 1 | 4 |
| 22193 | C. ramosum | XVIII | >512 | >512 | 1 | 4 |
| 22623 | C. ramosum | XVIII | >512 | >512 | 1 | 4 |
| 705 | Clostridium species | 0.5 | ≤0.03 | 0.125 | 1 | |
| 9906 | Clostridium species | >512 | 129 | 0.125 | 32 | |
| 10271 | Clostridium species | 1 | ≤0.03 | 2 | 0.5 | |
| 14157 | Clostridium species | 32 | >128 | 2 | >32 | |
| 16187 | Clostridium species | >512 | >128 | 2 | >32 | |
| 16338 | Clostridium species | >512 | >128 | 2 | >32 | |
| 19909 | Clostridium species | 0.25 | >128 | 16 | 16 | |
| 21472 | Clostridium species | 32 | >128 | 4 | >32 | |
| 21876 | Clostridium species | 0.25 | ≤0.03 | 1 | 8 | |
| 22256 | Clostridium species | 32 | ≤0.03 | 0.25 | 1 | |
| 22279 | Clostridium species | 32 | ≤0.03 | 0.25 | 1 | |
| 15596B | Clostridium species | 0.06 | ≤0.03 | 0.05 | 1 | |
| 18576W | Clostridium species | 32 | 0.06 | 0.125 | 2 | |
| 16034 | Flavonifractor plautii | 0.06 | ≤0.03 | 0.25 | 8 | |
| 22112 | Robinsoniella species | 0.06 | 2 | 2 | 2 | |
a
RMA, R.M. Alden Research Laboratory number.
b
SMT19969, Summit 19969.