TABLE 3.
Efficacy of cadazolid and vancomycin in the hamster model of CDADa
| Phase and study no. | Drug dose (mg/kg) and % survival |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cadazolid |
Vancomycin |
|||||||||
| During treatment, day 5 postinfection | ||||||||||
| 1 | VC, 0 | 10, 100 | 30, 100 | 100, 100 | VC, 0 | 50, 100 | ||||
| 2 | VC, 0 | 12.5, 100 | 25, 100 | 50, 100 | VC, ND | 12.5, 100 | 25, 100 | 50, 100 | ||
| 3 | VC, 20 | 0.3, 30 | 3, 100 | 30, 100 | 300, 100 | VC, ND | 0.3, 10 | 3, 100 | 30, 100 | 300, 100 |
| Posttreatment, day 28 postinfection | ||||||||||
| 1 | VC, 0 | 10, 40 | 30, 100 | 100, 80 | VC, 0 | 50, 100 | ||||
| 2 | VC, 0 | 12.5, 40 | 25, 60 | 50, 40 | VC, ND | 12.5, 30 | 25, 40 | 50, 100 | ||
| 3 | VC, 20 | 0.3, 20 | 3, 20 | 30, 0 | 300, 60 | VC, ND | 0.3, 0 | 3, 60 | 30, 80 | 300, 80 |
a
Hamsters (n = 10 or 11 per group) were treated for 5 days once daily. Survival rates (%) are in boldface. ND, not done; VC, vehicle control.