TABLE 1.

Urinary pH values and volumes of urine from six volunteers after single oral administration of nitroxoline or trimethoprim in the UIT/UBT study

Collection period	Urinary pH		Volume (ml)
	Mean ± SD	Median (range)	Mean ± SD	Median (range)
Before dosing	6.5 ± 0.8	6.2 (5.8–7.9)	1,039 ± 281	1,029 (702–1,409)
After nitroxoline (250 mg)
0–4 h	6.9 ± 0.6	6.9 (6.3–8.0)	878 ± 375	983 (346–1,362)
4–8 h	6.4 ± 0.6a	6.7 (5.6–7.0)	639 ± 276	593 (252–1,002)
8–12 h	6.8 ± 0.4	6.8 (6.3–7.5)	783 ± 368	804 (322–1,302)
12–24 h	6.3 ± 0.5	6.5 (5.5–6.7)	1,072 ± 595	924 (579–2,210)
After trimethoprim (200 mg)
0–4 h	7.3 ± 0.2	7.3 (6.9–7.6)	1,076 ± 401	1,165 (327–1,452)
4–8 h	7.2 ± 0.4a	7.3 (6.7–7.5)	711 ± 387	630 (355–1,413)
8–12 h	6.8 ± 0.3	6.9 (6.3–7.2)	924 ± 300	900 (466–1,259)
12–24 h	6.3 ± 0.5	6.2 (5.7–7.1)	1,207 ± 688	1,108 (328–2,277)

^aStatistically significant (P < 0.05).