TABLE 4.
Reciprocal UITs and areas under the 24-h UIT-time curve for nitroxoline and trimethoprim in the 6 volunteers tested
| Drug, urine type, and strain | UIT (median [range]) for the indicated collection period (h) |
AUIT24 | |||
|---|---|---|---|---|---|
| 0–4 | 4–8 | 8–12 | 12–24 | ||
| Nitroxoline | |||||
| Native urine | |||||
| Escherichia coli ATCC 25922 | 1 (0–2) | 0.5 (0–2) | 0 (0–1) | 0 (0–1) | 8 (0–24) |
| E. coli BN | 1 (0–2) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 4 (0–8)a |
| E. coli 1135121 | 0 (0–1) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 2 (0–4) |
| Klebsiella pneumoniae 1082 | 0.5 (0–1) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 4 (0–4) |
| Proteus mirabilis 1057 | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4) |
| Staphylococcus saprophyticus Ho94 | 0 (0–2) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–8)b |
| Urine at pH 5.5 | |||||
| E. coli ATCC 25922 | 3 (1–8) | 1 (0–8) | 0.5 (0–1) | 0 (0–0) | 18 (4–68)a,b |
| E. coli BN | 2 (0–2) | 1 (0–2) | 0 (0–1) | 0 (0–0) | 12 (0–20)a,b |
| E. coli 1135121 | 1 (0–2) | 0 (0–2) | 0 (0–1) | 0 (0–0) | 8 (0–16)a,b |
| K. pneumoniae 1082 | 1 (1–2) | 0.5 (0–1) | 0 (0–1) | 0 (0–0) | 8 (4–12)a,b |
| P. mirabilis 1057 | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4) |
| S. saprophyticus Ho94 | 2 (1–4) | 1 (0–4) | 0 (0–1) | 0 (0–0) | 12 (4–36)a,b |
| Urine at pH 8.0 | |||||
| E. coli ATCC 25922 | 0.5 (0–2) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 2 (0–12)a,b |
| E. coli BN | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4)a,b |
| E. coli 1135121 | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4)b |
| K. pneumoniae 1082 | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4)a,b |
| P. mirabilis 1057 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| S. saprophyticus Ho94 | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4)a,b |
| Trimethoprim | |||||
| Native urine | |||||
| E. coli ATCC 25922 | 64 (32–256) | 160 (32–256) | 48 (16–256) | 128 (128–128) | 2,944 (2,176–3,840) |
| E. coli BN | 64 (32–256) | 256 (32–256) | 48 (16–256) | 80 (32–128) | 2,368 (768–4,608)a |
| E. coli 1135121 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| K. pneumoniae 1082 | 8 (4–16) | 8 (2–16) | 8 (2–16) | 8 (4–64) | 208 (80–544) |
| P. mirabilis 1057 | 2 (2–4) | 2 (1–4) | 2 (2–4) | 2 (2–4) | 56 (44–88) |
| S. saprophyticus Ho94 | 8 (4–64) | 8 (4–32) | 8 (4–16) | 8 (4–32) | 200 (112–832) |
| Urine at pH 5.5 | |||||
| E. coli ATCC 25922 | 32 (16–256) | 32 (16–256) | 24 (8–256) | 128 (32–128) | 1,856 (608–4,608)a |
| E. coli BN | 24 (8–256) | 48 (8–256) | 16 (8–64) | 96 (16–128) | 1,840 (512–3,072)a,b |
| E. coli 1135121 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| K. pneumoniae 1082 | 4 (2–8) | 4 (1–8) | 2.5 (1–4) | 8 (2–16) | 124 (72–248)a |
| P. mirabilis 1057 | 4 (2–4) | 4 (2–4) | 2 (1–4) | 4 (4–4) | 88 (68–96) |
| S. saprophyticus Ho94 | 4 (1–16) | 4 (1–4) | 1 (1–4) | 4 (2–16) | 88 (52–288)a |
| Urine at pH 8.0 | |||||
| E. coli ATCC 25922 | 256 (128–256) | 256 (128–256) | 64 (64–256) | 128 (128–128) | 3,840 (2,816–4,608)a |
| E. coli BN | 160 (64–256) | 256 (16–256) | 160 (32–256) | 128 (32–128) | 3,840 (832–4,608)a,b |
| E. coli 1135121 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| K. pneumoniae 1082 | 16 (4–64) | 16 (2–32) | 8 (2–16) | 16 (4–128) | 384 (80–1,728)a |
| P. mirabilis 1057 | 4 (4–64) | 10 (4–16) | 4 (2–8) | 6 (4–16) | 144 (88–544) |
| S. saprophyticus Ho94 | 16 (8–64) | 24 (8–64) | 16 (8–16) | 32 (8–64) | 640 (224–992)a |
a
Indication of difference (P = 0.1 with the Mann-Whitney U test and P = 0.1 with the median test) for nitroxoline versus trimethoprim in urine at the same pH.
b
Indication of difference for native pH versus pH 8.0 versus pH 5.5 for nitroxoline or trimethoprim.