TABLE 5.
Reciprocal UBTs and areas under the 24-h UBT-time curve for nitroxoline and trimethoprim in the 6 volunteers tested
| Drug, urine type, and strain | UBT (median [range]) for the indicated collection period (h) |
AUBT24 | |||
|---|---|---|---|---|---|
| 0–4 | 4–8 | 8–12 | 12–24 | ||
| Nitroxoline | |||||
| Native urine | |||||
| Escherichia coli ATCC 25922 | 0 (0–2) | 0 (0–0) | 0 (0–1) | 0 (0–0) | 0 (0–12)a |
| E. coli BN | 0.5 (0–8) | 0 (0–0) | 0 (0–2) | 0 (0–2) | 2 (0–36)a |
| E. coli 1135121 | 0 (0–0) | 0 (0–4) | 0 (0–0) | 0 (0–0) | 0 (0–16) |
| Klebsiella pneumoniae 1082 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| Proteus mirabilis 1057 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| Staphylococcus saprophyticus Ho94 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| Urine at pH 5.5 | |||||
| E. coli ATCC 25922 | 1 (1–2) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 4 (4–12)a,b |
| E. coli BN | 1 (0–2) | 0 (0–2) | 0 (0–1) | 0 (0–0) | 4 (0–16)a |
| E. coli 1135121 | 0 (0–1) | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–8) |
| K. pneumoniae 1082 | 0 (0–2) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–8)a |
| P. mirabilis 1057 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| S. saprophyticus Ho94 | 0 (0–2) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–8)a |
| Urine at pH 8.0 | |||||
| E. coli ATCC 25922 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)ac |
| E. coli BN | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4)a |
| E. coli 1135121 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| K. pneumoniae 1082 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| P. mirabilis 1057 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| S. saprophyticus Ho94 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0)a |
| Trimethoprim | |||||
| Native urine | |||||
| E. coli ATCC 25922 | 96 (32–128) | 96 (32–128) | 32 (16–128) | 64 (64–64) | 1,664 (1,280–2,304)a |
| E. coli BN | 48 (32–128) | 128 (32–128) | 48 (16–64) | 64 (32–64) | 1,600 (704–2,048)a |
| E. coli 1135121 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
| K. pneumoniae 1082 | 12 (4–64) | 12 (2–16) | 8 (2–16) | 8 (0–64) | 248 (80–928)a |
| P. mirabilis 1057 | 3 (0–16) | 3 (0–16) | 2 (0–16) | 2 (1–64) | 54 (12–912)a |
| S. saprophyticus Ho94 | 8 (2–32) | 8 (4–16) | 6 (2–16) | 8 (2–32) | 192 (72–640)a |
| Urine at pH 5.5 | |||||
| E. coli ATCC 25922 | 32 (16–128) | 48 (16–64) | 24 (8–128) | 64 (32–64) | 1,088 (736–2,048)a,b |
| E. coli BN | 24 (8–64) | 24 (8–64) | 16 (8–64) | 48 (16–64) | 880 (512–1,408)a,b |
| E. coli 1135121 | 0 (0–1) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–4) |
| K. pneumoniae 1082 | 4 (1–8) | 4 (1–8) | 2 (1–4) | 6 (2–16) | 112 (64–240)a |
| P. mirabilis 1057 | 2 (0–16) | 2.5 (0–8) | 2 (0–8) | 2 (1–32) | 48 (12–464)a,b |
| S. saprophyticus Ho94 | 2 (1–16) | 2 (1–4) | 2 (1–4) | 4 (2–16) | 74 (40–288)a,b |
| Urine at pH 8.0 | |||||
| E. coli ATCC 25922 | 128 (64–128) | 128 (64–128) | 64 (64–128) | 64 (64–64) | 2,048 (1,792–2,048)a,b |
| E. coli BN | 96 (32–256) | 128 (16–256) | 64 (32–256) | 64 (32–64) | 1,920 (704–3,840)a,b |
| E. coli 1135121 | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–12) |
| K. pneumoniae 1082 | 12 (4–64) | 24 (2–32) | 8 (2–16) | 8 (1–64) | 248 (56–1,024)a |
| P. mirabilis 1057 | 3 (0–32) | 5 (0–16) | 2 (0–16) | 3 (1–64) | 74 (12–928)a,b |
| S. saprophyticus Ho94 | 16 (8–32) | 24 (8–32) | 12 (8–16) | 32 (8–64) | 592 (224–960)a,b |
a
Indication of difference (P = 0.1 with the Mann-Whitney U test and P = 0.1 with the median test) for nitroxoline versus trimethoprim in urine at the same pH.
b
Indication of difference for native pH versus pH 8.0 versus pH 5.5 for nitroxoline or trimethoprim.