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Metabolite analysis of nitroxoline in the urine of 6 volunteers at 0 to 24 h
| Metabolitea | Metabolite reaction | Relative area (%) |
|---|---|---|
| Nitroxoline | NAb | 1.0 |
| M1 | +O | 3.4 |
| M2 | +O+CH2 | 0.03 |
| M3 | +C2H2O (acetyl) | 0.1 |
| M4 | +C3H5NOS (cysteine) | 0.1 |
| M5 | +SO3 | 38.4 |
| M6 | +O+SO3 | 0.8 |
| M7 | +C6H8O6 | 55.7 |
| M8 | +O+C6H8O6 | 0.5 |
M5, nitroxoline sulfate; M7, nitroxoline glucuronide.
NA, not applicable.
