TABLE 8.
Urinary concentrations and excretion levels of trimethoprim in 6 volunteers
| Collection time (h) | Urinary concentrationa |
Urinary excretion levelb |
||||
|---|---|---|---|---|---|---|
| Mean ± SD (mg/liter) | CV (%) | Median (range) (mg/liter) | Mean ± SD (mg) | CV (%) | Median (range) (mg) | |
| 0–4 | 36.65 ± 21.9 | 59.9 | 27.43 (21.71–78.46) | 32.38 ± 6.31 | 19.5 | 30.05 (25.66–44.55) |
| 4–8 | 38.64 ± 16.90 | 43.7 | 37.71 (15.55–65.86) | 22.93 ± 3.93 | 17.1 | 21.54 (19.64–31.30) |
| 8–12 | 18.79 ± 3.50 | 18.6 | 18.68 (14.39–22.94) | 33.02 ± 9.34 | 28.3 | 30.81 (22.64–51.49) |
| 12–24 | 41.59 ± 35.10 | 84.4 | 28.04 (17.99–110.49) | 34.38 ± 3.88 | 11.3 | 34.55 (28.48–40.95) |
| 0–24 (total) | 122.70 ± 11.47 | 9.3 | 118.03 (108.74–140.47) | |||
a
CV, coefficient of variation.
b
Percentage of dose: mean ± SD, 61.35% ± 5.74%; median, 59.0%; range, 54.37% to 70.24%.