Mean bacterial densities over 96 h for single and sequential treatment regimens by isolate. (A) MRSA (isolate 412) single-treatment regimens; (B) MRSA (isolate 412) sequential treatment regimens; (C) hVISA (isolate 449) single-treatment regimens; (D) hVISA (isolate 449) sequential treatment regimens; (E) VISA (isolate 454) single-treatment regimens; (F) VISA (isolate 454) sequential treatment regimens. Closed diamonds, growth control; closed circles, vancomycin for 96 h; closed triangles, daptomycin for 96 h; closed squares, ceftaroline for 96 h; open triangles, vancomycin for 48 h followed by daptomycin for 48 h; open squares, vancomycin for 48 h followed by ceftaroline for 48 h.