TABLE 2.
Targeted and observed pharmacokinetics of all isolates against each regimen
| Antibiotic regimen | Pharmacodynamic target (AUC or fT>MICa) |
Peak (μg/ml) |
t1/2 (h) |
|||
|---|---|---|---|---|---|---|
| Target | Observed | Target | Observed | Target | Observed | |
| Vancomycin 1 g q12h | 105 | 106.5 ± 13.3 | 12.5 | 13.6 ± 1.6 | 9.0 | 9.6 ± 1.26 |
| Daptomycin 10 mg/kg q24h | 108 | 152.5 ± 33.9 | 13.9 | 12.6 ± 1.6 | 8.0 | 10.7 ± 2.03 |
| Ceftaroline 600 mg q12h | 60 | 61.8 ± 8.5 | 17.0 | 19.3 ± 1.9 | 2.7 | 2.5 ± 0.17 |
a
Shown are the AUC (μg · h/ml) of the dosing intervals for vancomycin and daptomycin and the fT>MIC (%) for ceftaroline.