TABLE 2.

Clinical features of Buruli ulcer patients with paradoxical reactions after administration of rifampin-streptomycin combination treatment daily for 2 weeks followed by rifampin-clarithromycin daily for 6 weeks

Characteristic	Patient no. and result
	1	2	3	4
Primary lesion form	Ulcer	Ulcer	Plaque	Nodule
Type of lesion reaction	Enlargement	Enlargement	Enlargement	Enlargement
Reaction site in relation to primary lesion	New site	Same site	Same site	Same site
Pus collection	No pus	No pus	No pus	Pus filled
Pain	Yes	No	No	Yes
Time of initial healing (no. of wks)	8	12	c	c
Onset(s) of reaction (no. of wks)	12	20, 32b	4	6
M. ulcerans culture result	Negative	Negative	Positive	Negative
Treatment(s) administered	Wound care	Wound care	Wound care, antibioticsc	Pus aspiration, antibioticsc
Time to complete healing (no. of wks)	20	39	30	18

^aThe lesion broke down at week 20 and improved but further enlarged at week 32.

^bThe lesion did not heal before the onset of the paradoxical reaction.

^cRoutine antibiotics for treatment of Buruli ulcer were continued until week 8.