FIG 6.

Increased uptake of radiolabeled TDF compared to that of TFV by murine cells. 3T3 cells (murine fibroblasts) were exposed to 0.1 or 1 μM [³H]TDF or [³H] TFV for 1 h at 37°C, washed three times to remove extracellular drug, and then solubilized, and intracellular radioactivity was measured. The protein content of each sample was determined in parallel, and results are presented as means plus standard deviations from two independent experiments conducted in duplicate. The asterisks indicate significant differences between TDF and TFV uptake by a t test (P < 0.05).