TABLE 4.
Distribution of tigecycline MICs for 650 Nocardia isolates
| Organism (n)a | No. of isolates for which the tigecycline MIC (μg/ml) was: |
|||||||
|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 | |
| N. abscessus complex (39) | 10 | 7 | 7 | 10 | 5 | 0 | 0 | 0 |
| N. abscessus complex, MDR (0) | ||||||||
| N. amamiensis (1) | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| N. amikacinitolerans (5) | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 0 |
| N. amikacinitolerans, MDR (3) | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
| N. aobensis (2) | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
| N. aobensis, MDR (1) | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| N. asteroides sensu stricto (2) | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
| N. beijingensis complex (18) | 2 | 2 | 1 | 4 | 7 | 1 | 1 | 0 |
| N. blacklockiae (1) | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| N. brasiliensis (88) | 7 | 36 | 21 | 18 | 5 | 1 | 0 | 0 |
| N. brasiliensis, MDR (34) | 3 | 9 | 12 | 6 | 3 | 1 | 0 | 0 |
| N. cyriacigeorgica (128) | 0 | 7 | 9 | 39 | 44 | 24 | 5 | 0 |
| N. cyriacigeorgica, MDR (12) | 0 | 0 | 2 | 4 | 3 | 2 | 1 | 0 |
| N. exalbida complex (1) | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| N. farcinica (102) | 0 | 2 | 0 | 2 | 6 | 18 | 58 | 16 |
| N. farcinica, MDR (65) | 0 | 1 | 0 | 1 | 4 | 5 | 40 | 14 |
| N. flavorosea (1) | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| N. ignorata (1) | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| N. neocaledoniensis (1) | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| N. niigatensis (1) | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| N. nova complex (162) | 4 | 1 | 11 | 25 | 41 | 51 | 28 | 1 |
| N. nova complex, MDR (2) | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| N. nova (132) | 4 | 1 | 9 | 22 | 32 | 38 | 25 | 1 |
| N. nova, MDR (2) | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| N. otitidiscaviarum (17) | 2 | 3 | 4 | 3 | 5 | 0 | 0 | 0 |
| N. paucivorans (5) | 0 | 4 | 0 | 0 | 1 | 0 | 0 | 0 |
| N. pseudobrasiliensis (7) | 0 | 0 | 0 | 1 | 2 | 1 | 3 | 0 |
| N. pseudobrasiliensis, MDR (7) | 0 | 0 | 0 | 1 | 2 | 1 | 3 | 0 |
| N. puris (1) | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| N. puris, MDR (1) | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| N. rhamnosiphila (2) | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| N. takedensis (1) | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| N. thailandia (1) | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| N. transvalensis complex (41) | 0 | 0 | 4 | 4 | 11 | 12 | 9 | 1 |
| N. transvalensis complex, MDR (20) | 0 | 0 | 0 | 1 | 4 | 8 | 6 | 1 |
| N. vermiculata (1) | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| N. yamanashiensis (1) | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Nocardia sp. (16) | 2 | 4 | 2 | 4 | 3 | 0 | 0 | 1 |
| Total (650) | 27 | 69 | 64 | 115 | 139 | 111 | 106 | 19 |
a
Distribution of tigecycline MICs for the species N. nova is provided independently from that for the larger N. nova complex. Multidrug-resistant (MDR) Nocardia spp. were defined as those with resistance to two or more of the most commonly used drugs (amikacin, ceftriaxone, TMP-SMX, and imipenem).