TABLE 6.
Treatment | Dose (mg/kg) | % parasitemia AUC relative to vehicle control (mean ± SD) |
|
---|---|---|---|
Expt 1 | Expt 2 | ||
Untreated | 0 | 100 ± 33 | 100 ± 21 |
Benznidazole | 50 | 32 ± 23 | 44 ± 9 |
Cz007 | 3 | NDa | 16 ± 3 |
10 | ND | 44 ± 10 | |
50 | ND | 46 ± 8 | |
Cz008 | 3 | ND | 23 ± 6 |
10 | 10 ± 2 | 25 ± 7 | |
50 | 35 ± 30 | ND |
ND, not determined.