TABLE 3.

Anidulafungin and micafungin ECVs for eight species of Candida based on MICs from 5 to 12 laboratories determined by the CLSI M27-A3 broth microdilution method

Antifungal agent tested	Species	No. of isolates	MIC (μg/ml)		ECV (μg/ml)a
			Range	Modeb	≥95%	≥97.5%	≥99%
Anidulafungin	C. albicans	8,210	0.008–2	0.03	0.06	0.12	0.12
	C. glabrata	2,680	0.008–4	0.06	0.12	0.12	0.25
	C. parapsilosis	3,976	0.008–8	2	4	8	8
	C. tropicalis	2,042	0.008–2	0.03	0.12	0.12	0.12
	C. krusei	322	0.008–2	0.06	0.12	0.25	0.25
	C. lusitaniae	234	0.008–1	0.25	1	1	1
	C. guilliermondii	222	0.03–4	1	4	8	8
	C. dubliniensis	131	0.015–4	0.03	0.12	0.12	0.12
Micafungin	C. albicans	7,874	0.008–4	0.015	0.03	0.03	0.03
	C. glabrata	3,102	0.008–4	0.015	0.03	0.03	0.03
	C. parapsilosis	3,484	0.015–4	1	2	4	4
	C. tropicalis	1,605	0.008–8	0.015	0.06	0.06	0.12
	C. krusei	617	0.015–1	0.06	0.25	0.25	0.25
	C. lusitaniae	258	0.008-≥16	0.25	0.5	0.5	1
	C. guilliermondii	234	0.015–8	0.5	2	2	4
	C. dubliniensis	117	0.008–8	0.06	0.12	0.12	0.12

^aCalculated ECVs comprising ≥95%, ≥97.5%, or ≥99% of the statistically modeled MIC population.

^bThe most frequent MIC.