TABLE 4.
Application of ECVs to MIC distributions of anidulafungin and micafungin for Candida strains tested for the presence of fks1 and fks2 mutations using the CLSI broth microdilution methoda
| Species (no. of isolates tested) | Antifungal agent | ECV (μg/ml) | No. of isolates by ECV category (no. of isolates showing mutations) |
|
|---|---|---|---|---|
| MIC ≤ ECV | MIC > ECV | |||
| C. albicans (52) | Anidulafungin | 0.12 | 42 (1) | 10 (10) |
| Micafungin | 0.03 | 31 (0) | 21 (11) | |
| C. glabrata (169) | Anidulafungin | 0.12 | 135 (2) | 34 (28) |
| Micafungin | 0.03 | 124 (0) | 45 (30) | |
| C. tropicalis (31) | Anidulafungin | 0.12 | 25 (1) | 6 (5) |
| Micafungin | 0.06 | 15 (0) | 16 (6) | |
| C. krusei (27) | Anidulafungin | 0.25 | 24 (0) | 3 (3) |
| Micafungin | 0.25 | 23 (0) | 4 (3) | |
| C. dubliniensis (2) | Anidulafungin | 0.12 | 1 (0) | 1 (1) |
| Micafungin | 0.12 | 1 (0) | 1 (1) | |