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Activity of cadazolid and comparators in DNA topoisomerase assays
| Enzyme | IC50 (μM) |
|||
|---|---|---|---|---|
| Cadazolidc | Linezolid | Ciprofloxacin | Moxifloxacin | |
| DNA gyrase (E. coli)a | 8–32 | >256 | 0.125–2 | 0.5 |
| DNA topoIV (E. coli)b | 32 to >50 | >256 | 2–8 | 8 |
| DNA gyrase (C. difficile)a | >50 | >256 | >256 | 32–128 |
| DNA gyrase (C. difficile)b | >50 | >256 | >256 | 32–128 |
Supercoiling.
Decatenation.
Maximal solubility of cadazolid in assay buffer (2 to 5% DMSO), 50 μM.
