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. 2014 Feb;58(2):901–908. doi: 10.1128/AAC.01831-13

TABLE 6.

MICs of selected clones of C. difficile obtained in single-step and multistep resistance development experiments compared to parent strains

C. difficile strain and selecting antibiotic Selection step, medium MIC (μg/ml)
Cadazolid Linezolid Moxifloxacin Fidaxomicin
NCTC 13366 (parent)
    None 0.25 2 32 0.25
    Cadazolid Step 1, agar 0.25 2 32 0.25
    Cadazolid Step 2, agar 0.5 2 32 0.25
    Cadazolid Step 3, agar 0.25 2 32 0.25
    Linezolid Step1, agar 0.5 8 32 0.25
    Linezolid Step 2, agar 0.5 8 32 0.25
    Linezolid Step 3, agar 0.5 8 32 0.25
    Fidaxomicin Step 1, agar 0.125 2 32 4
    Fidaxomicin Step 2, agar 0.125 2 32 128
ATCC 9689 (parent)
    None 0.25 2 2 ≤0.031
    Cadazolid Step 1, agar 0.25 2 2 ≤0.03
    Cadazolid Step 2, agar 0.5 4 2 ≤0.03
    Cadazolid Step 3, agar 0.5 4 2 ≤0.03
    Cadazolid Passage 13, liquid medium 0.25 2 2 ≤0.03
    Moxifloxacin Step 1, agar 0.06 2 4 0.008
    Moxifloxacin Step 2, agar 0.125 2 64 0.008
    Linezolid Step 1, agar 0.5 8 2 ≤0.03
    Linezolid Step 2, agar 0.5 8 2 ≤0.03
    Fidaxomicin Step 1, agar 0.25 4 2 2
    Fidaxomicin Step 2, agar 0.25 4 2 32
    Fidaxomicin Step 3, agar 0.125 4 2 >128
ATCC 700057 (quality control) 0.25 2 2 0.06