TABLE 2.
Protein name | TM1 amino acid sequenceb | Accession no. | Family |
---|---|---|---|
YqjA | FVLFVILFLENGLLPAAFLPGDS | NP417566 | DedA |
YghB | IVSVVYFVMFATLFLENGLLPAS(FLPGD)c | NP417482 | DedA |
BB0250 | VFFSLLILAGLNVPISEDAIVLMd | NP212384 | DedA |
MdfA | RLGRQALLFPLCLVLYEFSTYIG(ND)e | P0AEZ0 | 12-TMS family of the MFS |
TetL | LIWLCILSFFSVLNEMVLNVSLP | AAB09024 | 14-TMS family of the MFS |
EmrE | NPYIYLGGAILAEVIGTTLMKFS | P23895 | 4-TMS family of the SMR family |
Database sequences were analyzed for predicted membrane domains using SOSUI (45). This table is for illustration purposes only and is not a complete list of transport proteins. Abbreviations: TM1, transmembrane region 1; MFS, major facilitator superfamily; SMR, small multidrug resistance.
Conserved acidic amino acids are shown in bold.
YghB D51 is predicted to lie just outside TM1 but is also required for function (see Fig. S3 in the supplemental material).
BB0250 is an essential DedA family protein of Borrelia burgdorferi (36). E39 and D40 are each required for BB0250 to complement growth and cell division defects of BC202 (see Fig. S3 in the supplemental material).
E26 and D34 both play roles in transport by MdfA (35).