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Anti-AT MAbs prevent death in murine pneumonia model. C57BL/6J mice (n = 10) were injected i.p. with anti-AT MAb or R347 as a negative control. The animals were i.n. challenged 24 h later with 3 × 108 CFU of S. aureus USA300 (A), NRS261 (B), NRS382 (C) or SF8300 (D). Survival was monitored for 6 days postinfection. The asterisks indicate statistical significance versus the R347-treated group using the log-rank test.
