FIG 8.

Antibody plus antibiotic combination therapy reduces pulmonary damage. The histopathology of mouse lungs was evaluated 24 h postinfection with BAA-1556 and treatment 1 h postinfection as described above with the following: (A) R347, marked to severe inflammation with edema and necrosis and bacterial colonies (arrowhead); (B) LC10, severe inflammation with prominent bacterial colonies, necrosis, edema, hemorrhage (denoted by asterisk), and multifocal loss of alveolar architecture; (C) vancomycin, scattered bacterial colonies with areas of edema and necrosis (inset showing edema, proteinaceous material in alveolar space 40×); (D) vancomycin plus LC10, moderate inflammation with some bacterial colonies (arrowhead); (E) linezolid, mild to moderate neutrophilic inflammation with areas of necrosis (denoted by asterisk) and scattered bacterial colonies (arrowhead); (F) linezolid plus LC10, mild inflammation with isolated bacteria (inset showing bacterial colonies 40×). All photomicrographs are at ×10 magnification.