Clinical manifestations of yaws. (A) Early (primary) yaws: infectious skin lesion known as “mother yaw” on the ankle. (B) Early (secondary) yaws: infectious ulcero-papillomatous lesions on the arm. (C) Early (secondary) yaws: scaly maculae of irregular shape on the knee. (D) Early (secondary) yaws: plantar hyperkeratosis with painful cracks and fissures. (E) Fusiform swelling of the fourth digit in a yaws patient with dactylitis. (F) Saber shin, caused by chronic osteitis. (Panels A, C, and D are courtesy of Cynthia Kwakye and the Ghana National Yaws Eradication Program, reproduced with permission. Panel B is courtesy of Christina Widaningrum-Mkes and the Ministry of Health of Indonesia, reproduced with permission. Panels E and F were originally taken by Laurent Ferradini and are reprinted from reference 336, published under a Creative Commons license.)