TABLE 1.
Summary of clinical data and multiple sampling time points of HIV-infected participants
| Characteristic | Result (mean ± SD) for HIV-uninfected participants at time point 1 (n = 12) | Result (mean ± SD) for HIV-positive participants at time point: |
|||
|---|---|---|---|---|---|
| 1 (n = 36) | 2 (n = 13) | 3 (n = 12) | 4 (n = 6) | ||
| Average EDI (days)a | 129 ± 72 | 161 ± 68 | 346 ± 267 | 617 ± 396 | |
| CD4 cells/μl (%)b | 1,313 ± 409 (54 ± 9) | 727 ± 310 (33 ± 10) | 804 ± 280 (34 ± 9) | 738 ± 341 (30 ± 8) | 684 ± 256 (29 ± 7) |
| CD8 cells/μl (%)b | 694 ± 184 (29 ± 4) | 1,282 ± 846 (55 ± 11) | 1,246 ± 412 (53 ± 8) | 1,508 ± 914 (59 ± 9) | 1,334 ± 595 (58 ± 7) |
| Percent activatedc CD4 | 10 ± 3 | 18 ± 7 | 17 ± 9 | 17 ± 7 | 16 ± 7 |
| Percent activatedc CD8b | 4 ± 2 | 30 ± 20 | 31 ± 16 | 27 ± 10 | 20 ± 7 |
| Blood viral RNA (ln[copies/μl]) | 11.01 ± 1.86 | 11.24 ± 1.52 | 10.97 ± 1.10 | 10.32 ± 1.16 | |
| Seminal fluid viral RNA (ln[copies/μl]) | 6.89 ± 2.49 | 6.77 ± 4.42 | 6.90 ± 3.98 | 7.76 ± 1.36 | |
| Peripheral blood HIV DNA (copies/106 cells) | 98.6 ± 205 | 31.7 ± 69.1 | 55.5 ± 140 | 28.7 ± 27.2 | |
| Soluble CD14 (ng/ml) | 1,007 ± 170 | 1,285 ± 297 | 1,197 ± 258 | 1,157 ± 176 | 1,096 ± 986 |
a
Estimated duration of infection.
b
P < 0.001 comparing HIV-positive versus controls by Student's t test.
c
RA− CD38+ cells.