TABLE 4.

Log₂ fold regulation obtained from the microarray experiment of L. kluyveri genes related to pyrimidine metabolism in response to different sole nitrogen sources^a

L. kluyveri name	S. cerevisiae homolog	Sequence ID	Log2 fold regulation in response to:
			Uracil	Dihydrouracil	Uridine	Ammonia
URC1	None	Contig145.1.A:821	9.703	4.158	10.131	−2.016
URC2	YDR520C	Skluy_39.6.2:2	1.715	0.726	0.939	−0.418
URC3,5	DUR1,2	Skluy_36.1.5:5	5.264	1.554	4.326	−0.406
URC4	None	Contig31.2.A:628	8.410	4.048	8.012	−0.501
URC6	FUR1	Skluy_1.3.12:12	5.465	4.622	4.502	0.080
PYD2	None	Skluy_13.2.3:3	3.721	6.908	0.839	−0.078
PYD3	None	Contig147.1.A:1027	3.590	9.015	2.798	−0.106
PYD4	UGA1	Skluy_29.2.17:17	0.585	1.213	−0.441	−0.941
URC8	YMR226C	Skluy_76.1.28:28	3.819	4.984	4.161	−0.201
DAL4	DAL4	Skluy_54.3.14:14	4.280	0.986	3.090	0.107
DAL5	DAL5	Skluy_39.4.2:2	5.951	1.801	5.786	−0.121
DAL5 homolog	DAL5	Skluy_40.3.7:7	−0.513	1.105	−1.614	−1.609
FUI1	FUI1	Skluy_32.2.16:16	5.728	2.406	6.070	−1.632
FUI1 homolog	FUI1	SAKL0H03498gb	NA	NA	NA	NA
FUR4	FUR4	Skluy_182.1.2:2	3.890	5.903	2.406	−0.211
SAKL0A07480	Nonec	Skluy_104.1.4:4	4.626	3.581	3.061	−1.632
DUR3	DUR3	Skluy_31.2.8:8	4.483	1.749	3.580	−0.351

^aCells grown on single-nitrogen-source media were used, and the expression under the four conditions was compared to that in cells grown on media with proline as the nitrogen source. The log₂ fold regulation was calculated by logarithmically normalizing the sample/reference ratio of the values recovered from the scanned arrays. NA, not applicable.

^bThe oligonucleotide matching this gene could not be identified; therefore, its systematic name found in the Génolevures database was used.

^cWeakly similar to VBA2 (YBR293W).