TABLE 3.
Genome comparisons between two species and between NC and CL isolatesa
| Parameter | E. faecium (n = 31) | E. faecalis (n = 38) | Significanceb (t test) |
E. faecium |
E. faecalis |
||||
|---|---|---|---|---|---|---|---|---|---|
| NC (n = 10) | CL (n = 20) | Significance | NC (n = 7) | CL (n = 25) | Significance | ||||
| Genome size (kb) | 2,847.2 ± 122.1 | 3,000.8 ± 143.0 | P < 0.001 | 2,742.4 ± 99.4 | 2,897.8 ± 101.5 | P < 0.001 | 2,950.0 ± 121.9 | 3,027.0 ± 144.8 | NS |
| No. of CDS | 3,122.5 ± 132.1 | 3,247.6 ± 180.9 | P < 0.01 | 2,999.7 ± 107.5 | 3,182.0 ± 101.8 | P < 0.001 | 3,187.4 ± 168.6 | 3,276.9 ± 178.2 | NS |
| G+C content (%) | 37.9 ± 0.2 | 37.3 ± 0.2 | P < 0.001 | 38.0 ± 0.1 | 37.8 ± 0.2 | P < 0.05 | 37.4 ± 0.1 | 37.3 ± 0.2 | NS |
| No. of VF genesc | 14.0 ± 3.3 | 44.7 ± 4.1 | NA | 11.4 ± 2.4 | 15.4 ± 2.9 | P < 0.001 | 43.1 ± 3.0 | 45.3 ± 4.4 | NS |
| No. of AR genesd | 2.9 ± 2.3 | 5.7 ± 2.2 | P < 0.001 | 1.3 ± 2.4 | 3.8 ± 1.8 | P < 0.05 | 5.4 ± 2.8 | 6.2 ± 2.0 | NS |
| No. of ME genese | 97.1 ± 35.8 | 107.3 ± 27.8 | NS | 62.0 ± 24.0 | 111.8 ± 26.5 | P < 0.001 | 103.9 ± 30.5 | 110.6 ± 25.7 | NS |
Values are shown as means ± standard deviations.
P values were calculated by Student's t test. NA and NS indicate not analyzed and no significance, respectively.
Comparisons between virulence factor gene numbers were not applicable, because the genes were selected using different criteria depending on the species. Extensively studied VF genes were used for these comparisons (for more detail, see the supplemental material).
Known AR genes from the antibiotic resistance gene database (ARDB) (for more detail, see the supplemental material).
ME genes were regarded to be all phage, transposon, transposase, integrase, or insertion sequences (IS) designated according to the genome annotations.