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Simplified scheme of allosteric regulation of the central metabolism and lysine synthesis pathways in C. glutamicum. Feedback inhibitions of PEPC by aspartate and malate and AK by threonine and lysine strictly control the metabolic flux to lysine synthesis pathway. Dotted arrows represent pathways consisting of several reactions. PC, pyruvate carboxylase, PEPCK, phosphoenolpyruvate carboxykinase; AK, aspartokinase.
