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Predicted structure of MclS from M. catarrhalis. Bioinformatic data predict that MCORF 820 (renamed mclS) encodes a CLS. The presence of two HKD motifs (aa 186 to 193 and aa 436 to 443) indicates that MclS is a member of the PLD superfamily. The HKD motifs are thought to associate to form the active site of the enzyme. A signal peptide (aa 1 to 23) and lipid attachment site (aa 24) were predicted at the N terminus, thereby characterizing MclS as a putative lipid-anchored protein.
