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. 2014 Jan;196(2):210–226. doi: 10.1128/JB.00997-13

TABLE 2.

Comparison of essential gene predictions

Gene category Locus tag:
 Gene abbreviation(s) Enzyme name EC no.
B. cenocepacia B. multivorans
iBC unique essential genes BCAL0800 prs Ribose-phosphate pyrophosphokinase 2.7.6.1
BCAL0902 d,d-Heptose 1,7-bisphosphate phosphatase
BCAL2356 Phosphatidylserine decarboxylase 4.1.1.65
BCAL3389 tktA Transketolase 2.2.1.1
BCAL3428 nrdB Ribonucleotide-diphosphate reductase subunit β 1.17.4.1
BCAL3429 Ribonucleotide-diphosphate reductase subunit α 1.17.4.1
Common essential genes BCAL0162 Bmul_0198 gmhA Phosphoheptose isomerase 5.3.1.28
BCAL0508 Bmul_3079 Lipid A biosynthesis lauroyl acyltransferase 2.3.1.-
BCAL0509 Bmul_3078 metK S-Adenosylmethionine synthetase 2.5.1.6
BCAL0612 Bmul_2976 glmU UDP-N-acetylglucosamine pyrophosphorylase 2.7.7.23
BCAL0743 Bmul_0450 gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1.1.1.94
BCAL0817 Bmul_0528 kdsC Putative 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase 3.1.3.45
BCAL0818 Bmul_0529 Putative arabinose 5-phosphate isomerase 5.3.1.13
BCAL1269 Bmul_2021 glmM Phosphoglucosamine mutase 5.4.2.10
BCAL1281 Bmul_1997 Hypothetical protein (ornithine-acyl-ACP N-acyltransferase in Burkholderia sp. strain 383)
BCAL1556 Bmul_1683 rpiA Ribose-5-phosphate isomerase A 5.3.1.6
BCAL1887 Bmul_1460 ndk Nucleoside diphosphate kinase 2.7.4.6
BCAL1987 Bmul_1360 purL Phosphoribosylformylglycinamidine synthase 6.3.5.3
BCAL2061 Bmul_1287 guaA GMP synthase 6.3.5.2
BCAL2078 Bmul_1270 lpxB Lipid A disaccharide synthase 2.4.1.182
BCAL2079 Bmul_1269 lpxA UDP-N-acetylglucosamine acyltransferase 2.3.1.129
BCAL2080 Bmul_1268 fabZ (3R)-Hydroxymyristoyl-ACP dehydratase 4.2.1.-
BCAL2081 Bmul_1267 lpxD UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase 2.3.1.191
BCAL2089 Bmul_1259 pyrH Uridylate kinase 2.7.4.-
BCAL2101 Bmul_1247 dapD 2,3,4,5-Tetrahydropyridine-2,6-carboxylate N-succinyltransferase 2.3.1.117
BCAL2103 Bmul_1245 dapE Succinyl-diaminopimelate desuccinylase 3.5.1.18
BCAL2146 Bmul_1207 ask Aspartate kinase 2.7.2.4
BCAL2154 Bmul_1199 UDP-2,3-diacylglucosamine hydrolase 3.6.1.54
BCAL2180 Bmul_1162 2-Dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55
BCAL2181 Bmul_1161 pyrG CTP synthetase 6.3.4.2
BCAL2289 Bmul_1080 Glutamate racemase
BCAL2355 Bmul_1017 Putative phosphatidyltransferase 2.7.8.8
BCAL2388 Bmul_0984 Hypothetical protein (glucose-1-phosphate adenylyltransferase in iKF1028)
BCAL2389 Bmul_0983 purD Phosphoribosylamine-glycine ligase 6.3.4.13
BCAL2403 Bmul_0965 Putative LPS core biosynthesis protein 2.4.-.-
BCAL2759 Bmul_0751 Tetraacyldisaccharide 4′-kinase 2.7.1.130
BCAL2761 Bmul_0749 kdsB 3-Deoxy-manno-octulosonate cytidylyltransferase 2.7.7.38
BCAL2770 Bmul_0740 Putative glycerol-3-phosphate acyltransferase PlsY 2.3.1.15
BCAL2836 Bmul_0675 purK Phosphoribosylaminoimidazole carboxylase ATPase subunit 4.1.1.21
BCAL2837 Bmul_0674 purE Phosphoribosylaminoimidazole carboxylase catalytic subunit 4.1.1.21
BCAL2838 Bmul_0673 purC Phosphoribosylaminoimidazole-succinocarboxamide synthase 6.3.2.6
BCAL2912 Bmul_2218 thyA Thymidylate synthase 2.1.1.45
BCAL2944 Bmul_2251 hldD ADP-l-glycero-d-manno-heptose-6-epimerase 5.1.3.20
BCAL2951 Bmul_2258 cmk Cytidylate kinase 2.7.4.14
BCAL3012 Bmul_2401 gmk Guanylate kinase 2.7.4.8
BCAL3110 Bmul_2494 waaA 3-Deoxy-d-manno-octulosonic-acid transferase 2.4.99.12
BCAL3113 Bmul_2497 manB Phosphomannomutase 5.4.2.2
BCAL3133 Bmul_2598 rmlC dTDP-4-keto-6-deoxy-d-glucose 3,5-epimerase 5.1.3.13
BCAL3134 Bmul_2597 rmlA Glucose-1-phosphate thymidylyltransferase 2.7.7.24
BCAL3239 Bmul_4484 Glucosyltransferase
BCAL3261 Bmul_2624 purM Phosphoribosylaminoimidazole synthetase 6.3.3.1
BCAL3336 Bmul_2693 purH Phosphoribosylaminoimidazolecarboxamide formyltransferase 2.1.2.3
BCAL3361 Bmul_2717 purB Adenylosuccinate lyase 4.3.2.2
BCAL3397 Bmul_2756 Putative phosphatidylglycerophosphatase 3.1.3.27
BCAL3460 Bmul_2834 ddl d-Alanine-d-alanine ligase 6.3.2.4
BCAL3461 Bmul_2835 murC UDP-N-acetylmuramate-l-alanine ligase 6.3.2.8
BCAL3462 Bmul_2836 murG Undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase 2.4.1.227
BCAL3464 Bmul_2838 murD UDP-N-acetylmuramoyl-l-alanyl-d-glutamate synthetase 6.3.2.9
BCAL3465 Bmul_2839 mraY Phospho-N-acetylmuramoyl-pentapeptide-transferase 2.7.8.13
BCAL3466 Bmul_2840 murF UDP-N-acetylmuramoylalanyl-d-glutamyl-2,6-diaminopimelate-d-alanyl-d-alanyl ligase 6.3.2.10
BCAL3467 Bmul_2841 murE UDP-N-acetylmuramoylalanyl-d-glutamate-2,6-diaminopimelate ligase 6.3.2.13
BCAM0683 Bmul_3371 ceoR LysR family regulatory protein
BCAM0986 Bmul_4626 asd Aspartate-semialdehyde dehydrogenase 1.2.1.11
BCAM0998 Bmul_4615 purF Amidophosphoribosyltransferase 2.4.2.14
BCAM1337 Bmul_4402 Glycosyltransferase
BCAM2044 Bmul_3751 Putative asparagine synthetase 6.3.5.4
iBM unique essential genes Bmul_0742 murB UDP-N-acetylenolpyruvoylglucosamine reductase 1.1.1.158
Bmul_1262 Phosphatidate cytidylyltransferase 2.7.7.41
Bmul_2179 3-Oxoacyl-(acyl carrier protein) synthase II 2.3.1.179
Bmul_2182 fabD1, fabD2 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase 3.5.1.108
Bmul_2183 fabH1, fabH2 3-Oxoacyl-ACP synthase 2.3.1.41
Bmul_2184 plsX Putative glycerol-3-phosphate acyltransferase 2.3.1.15
Bmul_2221 Dihydrofolate reductase 1.5.1.3
Bmul_2735 dapB Dihydrodipicolinate reductase 1.3.1.26
Bmul_2829 lpxC UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase 3.5.1.108
Bmul_3080 dapF Diaminopimelate epimerase 5.1.1.7
Bmul_3287 prpB 2-Methylisocitrate lyase 4.1.3.30
Bmul_3288 Methylcitrate synthase 2.3.3.5
Bmul_4654 prpD 2-Methylcitrate dehydratase 4.2.1.79