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mTORC1 promotes HIF-1 transcriptional activity in HT1080 cells. (A and B) mTOR promoted HIF-1α CAD activity in HT1080 cells (A) but not in HEK293 cells (B). (C) Knockdown of raptor but not rictor decreased HIF-1α CAD activity. (D) Knockdown of known mTOR target genes did not affect HIF-1α CAD activity in HT1080 cells. The data in panels A to D were analyzed with the Student t test. **, P < 0.01.
