Receiver operating characteristic (ROC) curves for host biomarkers. Each point on an ROC curve is the fraction of bTB-positive cattle (true-positive rate) versus the corresponding fraction of negative bTB-exposed cattle (false-positive rate). VDBP is the most reliable biomarker (AUC, 0.8860), fetuin-A is a moderately reliable biomarker (AUC, 0.7741), and alpha-1 antitrypsin is an unreliable biomarker (AUC, 0.5425).