FIG 5.

An overview of clinical and metagenomic data for patient CF7. This patient was clinically defined as a nonresponder. The FEV₁% is illustrated across a 520-day period, and a red diamond indicates the baseline FEV₁%; the spike at the end of the FEV₁% graph indicates the effect of lung transplantation. The resistance profile line shows the results from laboratory resistance tests on clinically cultured microbes, obtained at the time point immediately below their placement. The first sample was collected during the onset of a clinically defined exacerbation, time point 0. The medications prescribed during each chronic and acute round of therapy are shown in the time line. The length of the black line corresponds to the duration of therapy. Acute therapy is represented as follows: M, meropenem; Ctx, ceftriaxone; Ctz, ceftazidime; PT, piperacillin-tazobactam; Cp, ciprofloxacin; T, tobramycin; G, gentamicin; Pred, prednisone; Imp, imipenem; Azt, aztreonam; Lz, linezolid; Col, colistin; Ampho, inhaled amphotericin; and Cayston, inhaled aztreonam.