TABLE 1.
Correlation of phenotypic ethambutol susceptibility with embB mutations in MDR TB strains
| DST method and resulta | No. of isolates with sequencing resultb |
Concordance rate (%)c |
|||
|---|---|---|---|---|---|
| R | S | For EMB-resistant strains | For EMB-susceptible strains | Overall | |
| Proportional | 61.7 | 85.7 | 76.6 | ||
| R | 50 | 31 | |||
| S | 11 | 66 | |||
| MIC | 83.6 | 89.7 | 87.3 | ||
| R | 51 | 10 | |||
| S | 10 | 87 | |||
a
R, resistant; S, susceptible.
b
R, having a mutation in the EMB resistance-determining region of embB; S, having a wild-type locus.
c
Concordance rates were determined on the basis of using phenotypic DST as the standard.