FIG 3.

Role of S100 alarmins in the PMN response during infection. Quantification of vaginal Candida burden (A) and vaginal PMNs (B). The number of CFU per 100 μl of lavage fluids from estrogenized S100A8- and S100A9-deficient or C57BL/6 wild-type mice inoculated with C. albicans was assessed on day 4 postinoculation. PMNs in vaginal lavage fluid were identified by Pap smear staining and enumerated in 5 high-powered fields (magnification, ×400) per mouse. The figure presents cumulative data from three repeats with 10 mice per group. ***, P < 0.0001 compared to the wild-type control group. SEM, standard error of the mean.